The purpose of this research was to develop Mouth dissolving tablets of Escitalopram oxalate using natural superdisintegrants (Abelmuscus esculentus and Trigonella foenum graceum) in different concentrations. Mucilage of Abelmuscus esculentus and seeds of Trigonella foenum graceum were extracted, evaluated for the organoleptic, physicochemical and phytochemical parameters. The dried mucilage was used as superdisintegrant for the preparation of mouth dissolving tablets by direct compression method. The blends were evaluated for the precompressional parameters and all the formulations were found to possess good flow properties. Tablets were compressed by direct compression technique, evaluated for weight variation, hardness, thickness, friability, water absorption, disintegration time, dispersion time, drug content and dissolution studies. The drug release profiles of the two superdisintegrants were compared and the optimized formula was subjected to wet granulation using PVP in ethanol as the dry binder. The results showed that the tablets containing dried mucilage of Abelmuscus esculentus as superdisintegrant using direct compression as the best formula and it followed first order release kinetics. Among ten formulations F5 showed highest drug release of 98.24 % than other formulations. The tablets were found to be stable during the accelerated stability studies conducted for three months at 40±2°C/75±5% RH.
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